Last data update: May 13, 2024. (Total: 46773 publications since 2009)
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A measles IgM rapid diagnostic test to address challenges with national measles surveillance and response in Malaysia
Senin A , Noordin NM , Sani JAM , Mahat D , Donadel M , Scobie HM , Omar A , Chem YK , Zahari MI , Ismail F , Rahman RA , Hussin HM , Selvanesan S , Aziz ZA , Arifin Wnawm , Bakar RSA , Rusli N , Zailani MH , Soo P , Lo YR , Grabovac V , Rota PA , Mulders MN , Featherstone D , Warrener L , Brown DW . PLoS One 2024 19 (3) e0298730 INTRODUCTION: A lateral flow rapid diagnostic test (RDT) enables detection of measles specific immunoglobulin M (IgM) antibody in serum, capillary blood, and oral fluid with accuracy consistent with enzyme immunoassay (EIA). The objectives of the study were: 1) to assess measles RDT inter-reader agreement between two clinic staff; 2) to assess the sensitivity and specificity of the measles RDT relative to standard surveillance testing in a low transmission setting; 3) to evaluate the knowledge, attitudes, and practices of staff in clinics using the RDT; and 4) to assess the impact of RDT testing on the measles public health response in Malaysia. MATERIALS AND METHODS: The clinic-based prospective evaluation included all suspected measles cases captured by routine measles surveillance at 34 purposely selected clinics in 15 health districts in Malaysia between September 2019 and June 2020, following day-long regional trainings on RDT use. Following informed consent, four specimens were collected from each suspected case, including those routinely collected for standard surveillance [serum for EIA and throat swabs for quantitative reverse transcriptase polymerase chain reaction (RT-qPCR)] together with capillary blood and oral fluid tested with RDTs during the study. RDT impact was evaluated by comparing the rapidity of measles public health response between the pre-RDT implementation (December 2018 to August 2019) and RDT implementation periods (September 2019 to June 2020). To assess knowledge, attitudes, and practices of RDT use, staff involved in the public health management of measles at the selected sites were surveyed. RESULTS: Among the 436 suspect cases, agreement of direct visual readings of measles RDT devices between two health clinic staff was 99% for capillary blood (k = 0.94) and 97% for oral fluid (k = 0.90) specimens. Of the total, 45 (10%) were positive by measles IgM EIA (n = 44, including five also positive by RT-qPCR) or RT-qPCR only (n = 1), and 38 were positive by RDT (using either capillary blood or oral fluid). Using measles IgM EIA or RT-qPCR as reference, RDT sensitivity using capillary blood was 43% (95% CI: 30%-58%) and specificity was 98% (95% CI: 96%-99%); using oral fluid, sensitivity (26%, 95% CI: 15%-40%) and specificity (97%, 95% CI: 94%-98%) were lower. Nine months after training, RDT knowledge was high among staff involved with the public health management of measles (average quiz score of 80%) and was highest among those who received formal training (88%), followed by those trained during supervisory visits (83%). During the RDT implementation period, the number of days from case confirmation until initiation of public response decreased by about 5 days. CONCLUSION: The measles IgM RDT shows >95% inter-reader agreement, high retention of RDT knowledge, and a more rapid public health response. However, despite ≥95% RDT specificity using capillary blood or oral fluid, RDT sensitivity was <45%. Higher-powered studies using highly specific IgM assays and systematic RT-qPCR for case confirmation are needed to establish the role of RDT in measles elimination settings. |
Rapid diagnostic tests to address challenges for global measles surveillance.
Brown DW , Warrener L , Scobie HM , Donadel M , Waku-Kouomou D , Mulders MN , Rota PA . Curr Opin Virol 2020 41 77-84 Recently, a lateral flow rapid diagnostic test (RDT) with good accuracy has been described. This test enables measles specific IgM antibody detection in serum, capillary blood and oral fluid. RDTs have the potential to transform measles surveillance by allowing real-time case confirmation outside of central/regional laboratories and by facilitating a timely public health response. Measles virus genes can also be amplified and sequenced consistently from dried IgM-positive RDTs stored outside of cold chain, which will enable more complete virologic surveillance. Critical questions remain regarding operational use of RDTs as part of global measles surveillance. Projects to evaluate RDT use as part of national surveillance programs and to commercialize the RDT are underway. |
Home-based records and vaccination appointment stickers as parental reminders to reduce vaccination dropout in Indonesia: A cluster-randomized controlled trial
Wallace AS , Peetosutan K , Untung A , Ricardo M , Yosephine P , Wannemuehler K , Brown DW , McFarland DA , Orenstein WA , Rosenberg ES , Omer SB , Daniels D . Vaccine 2019 37 (45) 6814-6823 INTRODUCTION: Limited evidence is available about the effectiveness of strategies to remind caregivers when to bring children back for future vaccinations in low- and middle-income country settings. We evaluated the effectiveness of two reminder strategies based on home-based vaccination records (HBR) in Indonesia. METHODS: In this cluster-randomized controlled trial involving 3616 children <1year of age, 90 health facilities were randomly assigned to either a control group or one of two intervention groups: (1) HBR-only group, where healthcare workers provided an HBR to any child without an HBR during a vaccination visit and instructed the caregiver to keep it at home between visits, or (2) HBR+sticker group, where, in addition to HBR provision, healthcare workers placed vaccination appointment reminder stickers on the HBR. The primary outcome was receipt of the third dose of diphtheria-tetanus-pertussis-containing vaccine (DTPcv3) within 7months and the secondary outcome was receipt of a timely DTPcv3 dose. RESULTS: Control group DTPcv3 coverage was 81%. In intention-to-treat analysis, neither intervention group had significantly different DTPcv3 coverage compared with the control group (RR=0.94, 95% confidence interval [CI] 0.87; 1.02 for HBR-only group; RR=0.97, 95% CI 0.90; 1.04 for HBR+sticker group) by study end. However, children in the HBR+sticker group were 50% more likely to have received a DTPcv3 vaccination (RR=1.46, 95% CI 1.02, 2.09) within 60days of DTPcv1 vaccination, compared with children in the control group; children in the HBR-only group were not more likely to have done so (RR=1.05, 95% CI 0.71, 1.55). DISCUSSION: Reminder stickers had an immediate effect on coverage by improving the proportion of children who received a timely DTPcv3 dose but no effect on the proportion who received DTPcv3 after 7months. Coupling reminder stickers with strategies to address other reasons why children do not return for vaccination visits should be further explored. |
Susceptibility of Brazilian influenza A(H1N1)pdm09 viruses to neuraminidase inhibitors in the 2014-2016 seasons: Identification of strains bearing mutations associated with reduced inhibition profile.
Matos AR , Resende PC , Miranda MD , Garcia CC , Caetano BC , Lopes JCO , Debur MC , Cury ALF , Vianna LA , Lima MC , Schirmer M , Gubareva L , Hurt AC , Brown DW , Siqueira MM . Antiviral Res 2018 154 35-43 Neuraminidase inhibitors (NAIs) are the main class of antivirals currently used for the treatment of influenza infections. As influenza viruses are constantly evolving, drug-resistance can emerge resulting in reduced effectiveness of treatment. This study evaluated the presence of molecular markers associated with NAI susceptibility in 724 influenza A(H1N1)pdm09 positive samples from Brazilian surveillance system from the 2014-2016 seasons, including 76 isolates tested for oseltamivir (OST) susceptibility and 23 isolates also tested for zanamivir, peramivir and laninamivir susceptibility. We identified the H275Y (n=3) and I223K (n=1) NA substitutions, associated with reduced inhibition (RI) by the NAIs. Noteworthy, no epidemiological links were identified among the patients infected with the mutant viruses. Phylogenetic analysis from NA and hemagglutinin genes showed that mutant viruses were not clustered. All mutant virus strains carried the permissive substitutions V241I and N369K, in addition to the N386K, which has been shown to destabilize the NA structure. Functional NA analysis of one virus containing the H275Y mutation confirmed its highly RI profile to OST and peramivir and demonstrated that it had decreased viral replication and NA thermostability compared to the wild type virus. The remaining tested isolates presented normal inhibition profile to the NAIs tested. In conclusion, the overall frequency of influenza A(H1N1)pdm09 viruses bearing mutations associated with NAI RI was 0.6%, similar to what has been observed in recent global studies. |
Using seroprevalence and immunisation coverage data to estimate the global burden of Congenital Rubella Syndrome, 1996-2010: A systematic review
Vynnycky E , Adams EJ , Cutts FT , Reef SE , Navar AM , Simons E , Yoshida LM , Brown DW , Jackson C , Strebel PM , Dabbagh AJ . PLoS One 2016 11 (3) e0149160 BACKGROUND: The burden of Congenital Rubella Syndrome (CRS) is typically underestimated in routine surveillance. Updated estimates are needed following the recent WHO position paper on rubella and recent GAVI initiatives, funding rubella vaccination in eligible countries. Previous estimates considered the year 1996 and only 78 (developing) countries. METHODS: We reviewed the literature to identify rubella seroprevalence studies conducted before countries introduced rubella-containing vaccination (RCV). These data and the estimated vaccination coverage in the routine schedule and mass campaigns were incorporated in mathematical models to estimate the CRS incidence in 1996 and 2000-2010 for each country, region and globally. RESULTS: The estimated CRS decreased in the three regions (Americas, Europe and Eastern Mediterranean) which had introduced widespread RCV by 2010, reaching <2 per 100,000 live births (the Americas and Europe) and 25 (95% CI 4-61) per 100,000 live births (the Eastern Mediterranean). The estimated incidence in 2010 ranged from 90 (95% CI: 46-195) in the Western Pacific, excluding China, to 116 (95% CI: 56-235) and 121 (95% CI: 31-238) per 100,000 live births in Africa and SE Asia respectively. Highest numbers of cases were predicted in Africa (39,000, 95% CI: 18,000-80,000) and SE Asia (49,000, 95% CI: 11,000-97,000). In 2010, 105,000 (95% CI: 54,000-158,000) CRS cases were estimated globally, compared to 119,000 (95% CI: 72,000-169,000) in 1996. CONCLUSIONS: Whilst falling dramatically in the Americas, Europe and the Eastern Mediterranean after vaccination, the estimated CRS incidence remains high elsewhere. Well-conducted seroprevalence studies can help to improve the reliability of these estimates and monitor the impact of rubella vaccination. |
Global routine vaccination coverage, 2013
Harris JB , Gacic-Dobo M , Eggers R , Brown DW , Sodha SV . MMWR Morb Mortal Wkly Rep 2014 63 (46) 1055-8 In 1974, the World Health Organization (WHO) established the Expanded Program on Immunization to ensure that all children have access to routinely recommended vaccines. Since then, global coverage with the four core vaccines (Bacille Calmette-Guerin vaccine [for protection against tuberculosis], diphtheria-tetanus-pertussis vaccine [DTP], polio vaccine, and measles vaccine) has increased from <5% to ≥84%, and additional vaccines have been added to the recommended schedule. Coverage with the third dose of DTP vaccine (DTP3) by age 12 months is a key indicator of immunization program performance. Estimated global DTP3 coverage has remained at 83%-84% since 2009, with estimated 2013 coverage at 84%. Global coverage estimates for the second routine dose of measles-containing vaccine (MCV2) are reported for the first time in 2013; global coverage was 35% by the end of the second year of life and 53% when including older age groups. Improvements in equity of access and use of immunization services will help ensure that all children are protected from vaccine-preventable diseases. |
Physical activity and health-related quality of life: US adults with and without limitations
Brown DR , Carroll DD , Workman LM , Carlson SA , Brown DW . Qual Life Res 2014 23 (10) 2673-80 PURPOSE: The purpose of this study was to examine the dose-response relationship between physical activity (PA) and health-related quality of life (HRQOL) among adults with and without limitations. METHODS: We dichotomized HRQOL as ≥14 unhealthy (physical or mental) days (past 30 days), or <14 unhealthy days. By using a moderate-intensity minute equivalent, PA categories were as follows: inactive, 10-60, 61-149, 150-300, and >300 min/week. Persons with limitations reported having problems that limited their activities or required use of special equipment. Age-adjusted prevalence estimates and logistic regression analyses were performed with 2009 Behavioral Risk Factor Surveillance System data (n = 357,665), controlling for demographics, BMI, smoking, and heavy alcohol use. RESULTS: For adults without limitations, the odds of ≥14 unhealthy days were lower among adults obtaining any PA (10-60 min/week, AOR = 0.79, 95 % CI 0.70, 0.88), compared with those inactive. A quadratic trend (P < 0.001) indicated enhanced HRQOL with each PA level, but improvements were less marked between lower and upper sufficient PA categories (150-300 and >300 min/week). Because of a significant age interaction, persons with limitations were stratified by age (18-34, 35-64, and 65+ years). Findings for persons aged 35 years or older with limitations were similar to those without limitations. Lower odds of poor HRQOL for persons aged 18-34 years with limitations were associated with recommended levels of PA (150-300 min/week; AOR = 0.61, 95 % CI 0.43, 0.88 and >300 min/week; AOR = 0.58, 95 % CI 0.43, 0.80). CONCLUSIONS: PA is positively associated with HRQOL among persons with and without limitations. |
Breast and cervical cancer screening among women in Jordan: findings from the Behavioural Risk Factor Surveillance System - 2007
Al Nsour M , Brown DW , Tarawneh M , Haddadin R , Walk H . Open Breast Cancer J 2012 4 (1) 1-7 INTRODUCTION: Breast cancer is the most common cancer among women in Jordan. Age standardized incidence rate for cervical cancer has been estimated at 3.6 per 100,000 women. This report presents the results of breast and cervical cancer screening practices among a nationally representative sample of Jordanian women aged 35 years or above. METHOD: We used data from the third Jordan Behavioural Risk Factor Surveillance System (2007) among a nationally representative sample of Jordanian women aged >=35 years (n=1,157). Logistic regression was used to examine the associations between each of breast and cervical cancer screening practices and selected socio-demographic characteristics. RESULTS: Only 12.4% of women aged 35 years or older reported ever having a mammography. One fifth reported ever having a clinical breast examination at least once in their life time. Over one quarter (27.1%) of the women reported that they perform self-breast examination on monthly basis, and 41.7% reported ever having performed a self-breast examination. Among ever-married women aged 35 years or more, Pap smear test was performed by 27.8% during their life. The reported low practices have shown substantial differences across regions, age groups, level of education, family income, marital status, and source of medical services. CONCLUSION: The low reported cancer screening activities among women in Jordan calls for action. Data on current screening practices is a primary step to provide health professionals, and policy-makers with the information necessary to identify priorities and to facilitate cancer control, policy development, and planning. |
Improving global virologic surveillance for measles and rubella
Rota PA , Brown KE , Hubschen JM , Muller CP , Icenogle J , Chen MH , Bankamp B , Kessler JR , Brown DW , Bellini WJ , Featherstone D . J Infect Dis 2011 204 Suppl 1 S506-13 An important aspect of laboratory surveillance for measles and rubella is the genetic characterization of circulating wild-type viruses to support molecular epidemiologic studies and to track transmission pathways. Virologic surveillance that is sufficient to document the interruption of transmission of measles and rubella viruses will be an essential criterion for verification of elimination. Laboratories in the World Health Organization (WHO) Measles and Rubella Laboratory Network have worked to improve and expand virologic surveillance as many regions move toward elimination of measles and rubella/congenital rubella syndrome. As countries approach elimination, it will be necessary to obtain genetic information from as many chains of transmission as possible. In addition, baseline virologic surveillance, especially for rubella, needs to be improved in many countries. This report contains a summary of recent improvements to the methods used for virologic surveillance. |
Building a framework for global surveillance of the public health implications of adverse childhood experiences
Anda RF , Butchart A , Felitti VJ , Brown DW . Am J Prev Med 2010 39 (1) 93-8 In May 2009, the WHO and the National Center for Chronic Disease Prevention and Health Promotion (CDC, Atlanta GA) met in Geneva, Switzerland, to begin a collaborative effort to build a framework for public health surveillance that can be used to define the global health burden of adverse childhood experiences (ACEs). In addition to WHO and CDC staff, meeting participants included people working in the fields of public health and early child development from Canada, China, the former Yugoslav Republic of Macedonia, Philippines, Saudi Arabia, South Africa, Switzerland, and Thailand. Participants articulated their goal of forming a network aimed at advancing global understanding and measurement of ACEs through the exchange of information and the provision of technical expertise and support.1 | Viewing child maltreatment and related experiences as a set of exposures that have broad implications for human development and prevention of public health problems is a relatively new concept. Only since 2004 has child sexual abuse been included in the global burden of disease estimates of death and disability attributable to particular avoidable risk factors,2 and medical journals have recently begun to acknowledge the concept of abuse and related it as a major public health issue by raising awareness of the body of literature that supports this concept.3, 4 |
Trends in hospitalization with chronic obstructive pulmonary disease-United States, 1990-2005
Brown DW , Croft JB , Greenlund KJ , Giles WH . COPD 2010 7 (1) 59-62 Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States and a major cause of morbidity and disability. To update national estimates and examine trends for hospitalization with COPD between 1990 and 2005, we analyzed data from the National Hospital Discharge Survey (NHDS). The results indicated that an estimated 715,000 hospitalizations with COPD, or 23.6 per 10,000 population, occurred during 2005, an increase in the number and the rate of COPD hospitalizations since 1990 (370,000 hospitalizations; rate = 15.9 per 10,000 population). To reverse increases in the number of COPD hospitalizations and decrease the burden of COPD, public health programs should continue focused efforts to reduce total personal exposure to tobacco smoke, including passive smoke exposure; to occupational dusts and chemicals; and to other indoor and outdoor air pollutants linked to COPD. |
Smoking prevalence among US veterans
Brown DW . J Gen Intern Med 2009 25 (2) 147-9 BACKGROUND/OBJECTIVE: Cigarette smoking is a significant health problem within the US military. Data from the 2003-2007 Behavioral Risk Factor Surveillance System (BRFSS) were used to estimate and compare the prevalence of smoking among US veterans with that of adults who did not serve in the US armed forces. METHODS: Data from the BRFSS, a state-based random-digit dialed telephone survey supported by the Centers for Disease Control and Prevention, were used to estimate the prevalence of current smoking among adults (aged ≥18 years) who reported ever serving on active duty in the United States Armed Forces. We compared, by birth cohort, age-adjusted smoking prevalence among veterans with that of adults who did not serve in the military. RESULTS: A total of 224,169 US veterans participated during 2003-2007. The age-adjusted prevalence of smoking during the period was 27.0% (standard error, 0.36) among veterans and 21% (0.12) among non-veterans. For both groups, the prevalence decreased across years from 29% (0.79) in 2003 to 25% (0.82) in 2007 among veterans and from 23% (0.29) in 2003 to 20% (0.26) in 2007 among non-veterans. Among veterans, smoking prevalence was highest among men born between 1975-1984 (36%; 90%CI = 33.7-37.5) and those born between 1985-1989 (37%; 90%CI = 31.7-48.2) with lower prevalences among men born between 1945-1954 (26%; 90%CI = 25.1-26.3), 1955-1964 (33%; 90%CI = 32.3-34.3), and 1965-1974 (27%; 90%CI = 26.0-28.1). The prevalence of smoking was 43% (90%CI = 39.0-47.6) among veterans with self-reported coronary heart disease (CHD), greater than that for non-veterans with CHD (31%; 90%CI = 28.6-33.1). CONCLUSIONS: Although the prevalence of smoking has declined among US adults, there are opportunities to further reduce smoking among US veterans, particularly young veterans for whom the prevalence of smoking is similar to that of the US adult population during the late 1960s/early 1970s. Continued work is necessary to target the high smoking prevalence among veterans with CHD, a group for which smoking cessation is especially important. |
Adverse childhood experiences and the risk of premature mortality
Brown DW , Anda RF , Tiemeier H , Felitti VJ , Edwards VJ , Croft JB , Giles WH . Am J Prev Med 2009 37 (5) 389-96 BACKGROUND: Strong, graded relationships between exposure to childhood traumatic stressors and numerous negative health behaviors and outcomes, healthcare utilization, and overall health status inspired the question of whether these adverse childhood experiences (ACEs) are associated with premature death during adulthood. PURPOSE: This study aims to determine whether ACEs are associated with an increased risk of premature death during adulthood. METHODS: Baseline survey data on health behaviors, health status, and exposure to ACEs were collected from 17,337 adults aged >18 years during 1995-1997. The ACEs included abuse (emotional, physical, sexual); witnessing domestic violence; parental separation or divorce; and growing up in a household where members were mentally ill, substance abusers, or sent to prison. The ACE score (an integer count of the eight categories of ACEs) was used as a measure of cumulative exposure to traumatic stress during childhood. Deaths were identified during follow-up assessments (between baseline appointment date and December 31, 2006) using mortality records obtained from a search of the National Death Index. Expected years of life lost (YLL) and years of potential life lost (YPLL) were computed using standard methods. The relative risk of death from all causes at age < or =65 years and at age < or =75 years was estimated across the number of categories of ACEs using multivariable-adjusted Cox proportional hazards regression. Analysis was conducted during January-February 2009. RESULTS: Overall, 1539 people died during follow-up; the crude death rate was 91.0 per 1000; the age-adjusted rate was 54.7 per 1000. People with six or more ACEs died nearly 20 years earlier on average than those without ACEs (60.6 years, 95% CI=56.2, 65.1, vs 79.1 years, 95% CI=78.4, 79.9). Average YLL per death was nearly three times greater among people with six or more ACEs (25.2 years) than those without ACEs (9.2 years). Roughly one third (n=526) of those who died during follow-up were aged < or =75 years at the time of death, accounting for 4792 YPLL. After multivariable adjustment, adults with six or more ACEs were 1.7 (95% CI=1.06, 2.83) times more likely to die when aged < or =75 years and 2.4 (95% CI=1.30, 4.39) times more likely to die when aged < or =65 years. CONCLUSIONS: ACEs are associated with an increased risk of premature death, although a graded increase in the risk of premature death was not observed across the number of categories of ACEs. The increase in risk was only partly explained by documented ACE-related health and social problems, suggesting other possible mechanisms by which ACEs may contribute to premature death. |
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